Development of Peptidomimetic Inhibitors of a Newly Isolated Atrial Peptide-Degrading Enzyme

Toll et al. recently reported the isolation of a new atrial peptide-degrading enzyme (ADE) from bovine kidney that preferentially cleaves atrial peptide substrates at their Ser-Phe bond. ADE is inhibited by general protease inhibitors that inhibit either metallo or cysteine proteases. However, it is not inhibited by phosphoramidon, an inhibitor of neutral endopeptidase 24.11. The development of selective inhibitors of ADE would be useful for studying this new enzyme, and such inhibitors could serve as novel antihypertensive agents. This Article is from 'Peptides, Chemistry and Biology: Proceedings of the American Peptide Symposium (12th) Held in Cambridge, Massachusetts on 16-21 June 1991', AD-A256 113, p791-792.