Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes
The morbidity associated with open fractures and open fracture treatment is well established. An osteoinductive and osteoconductive bone graft substitute that prevents infection would decrease the number of procedures required to treat contaminated fractures by eliminating the need for surgical remo...
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| creator | Beardmore, Anthony A Brooks, Daniel E Wenke, Joseph C Thomas, Darryl B |
| description | The morbidity associated with open fractures and open fracture treatment is well established. An osteoinductive and osteoconductive bone graft substitute that prevents infection would decrease the number of procedures required to treat contaminated fractures by eliminating the need for surgical removal of cement beads and perhaps autograft harvest. We hypothesized that the combination of tobramycin impregnated calcium sulfate pellets and demineralized bone matrix would prevent the establishment of infection in a contaminated fracture model.
Published in The Journal of Bone & Joint Surgery, v87 n1 p107-112, Jan 23005. |
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Published in The Journal of Bone & Joint Surgery, v87 n1 p107-112, Jan 23005.</description><subject>Anatomy and Physiology</subject><subject>ANTIBIOTICS</subject><subject>BIOLOGICAL CONTAMINATION</subject><subject>BONE FRACTURES</subject><subject>DRUG DELIVERY</subject><subject>GRAFTS</subject><subject>Medicine and Medical Research</subject><subject>OPEN FRACTURES</subject><subject>Pharmacology</subject><subject>STAPHYLOCOCCUS AUREUS</subject><subject>SURGICAL TRANSPLANTATION</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2005</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZEh1TUtLTS7JLEvNSy0uVshPU_DJT07MUXDMK8lMyswvyUxWcEnNAUoXVSqUZ5ZkKPgXl6TmZ-allII1QbjJ-XC-U35eqm56UWJaiUJwaVJxSWZJaUlqMQ8Da1piTnEqL5TmZpBxcw1x9tBNAVoQD1SVl1oS7-jiaGZsZGpiaExAGgAIED0p</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Beardmore, Anthony A</creator><creator>Brooks, Daniel E</creator><creator>Wenke, Joseph C</creator><creator>Thomas, Darryl B</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>200501</creationdate><title>Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes</title><author>Beardmore, Anthony A ; Brooks, Daniel E ; Wenke, Joseph C ; Thomas, Darryl B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA6325413</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anatomy and Physiology</topic><topic>ANTIBIOTICS</topic><topic>BIOLOGICAL CONTAMINATION</topic><topic>BONE FRACTURES</topic><topic>DRUG DELIVERY</topic><topic>GRAFTS</topic><topic>Medicine and Medical Research</topic><topic>OPEN FRACTURES</topic><topic>Pharmacology</topic><topic>STAPHYLOCOCCUS AUREUS</topic><topic>SURGICAL TRANSPLANTATION</topic><toplevel>online_resources</toplevel><creatorcontrib>Beardmore, Anthony A</creatorcontrib><creatorcontrib>Brooks, Daniel E</creatorcontrib><creatorcontrib>Wenke, Joseph C</creatorcontrib><creatorcontrib>Thomas, Darryl B</creatorcontrib><creatorcontrib>ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Beardmore, Anthony A</au><au>Brooks, Daniel E</au><au>Wenke, Joseph C</au><au>Thomas, Darryl B</au><aucorp>ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes</btitle><date>2005-01</date><risdate>2005</risdate><abstract>The morbidity associated with open fractures and open fracture treatment is well established. An osteoinductive and osteoconductive bone graft substitute that prevents infection would decrease the number of procedures required to treat contaminated fractures by eliminating the need for surgical removal of cement beads and perhaps autograft harvest. We hypothesized that the combination of tobramycin impregnated calcium sulfate pellets and demineralized bone matrix would prevent the establishment of infection in a contaminated fracture model.
Published in The Journal of Bone & Joint Surgery, v87 n1 p107-112, Jan 23005.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | Anatomy and Physiology ANTIBIOTICS BIOLOGICAL CONTAMINATION BONE FRACTURES DRUG DELIVERY GRAFTS Medicine and Medical Research OPEN FRACTURES Pharmacology STAPHYLOCOCCUS AUREUS SURGICAL TRANSPLANTATION |
| title | Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes |
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