Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes

Effectiveness of Local Antibiotic Delivery with Osteoinductive Osteoconductive Bone-graft Substitutes

The morbidity associated with open fractures and open fracture treatment is well established. An osteoinductive and osteoconductive bone graft substitute that prevents infection would decrease the number of procedures required to treat contaminated fractures by eliminating the need for surgical remo...

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Bibliographische Detailangaben
Hauptverfasser: Beardmore, Anthony A, Brooks, Daniel E, Wenke, Joseph C, Thomas, Darryl B
Format: Report
Sprache:eng
Schlagworte:
Anatomy and Physiology
ANTIBIOTICS
BIOLOGICAL CONTAMINATION
BONE FRACTURES
DRUG DELIVERY
GRAFTS
Medicine and Medical Research
OPEN FRACTURES
Pharmacology
STAPHYLOCOCCUS AUREUS
SURGICAL TRANSPLANTATION
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Zusammenfassung:The morbidity associated with open fractures and open fracture treatment is well established. An osteoinductive and osteoconductive bone graft substitute that prevents infection would decrease the number of procedures required to treat contaminated fractures by eliminating the need for surgical removal of cement beads and perhaps autograft harvest. We hypothesized that the combination of tobramycin impregnated calcium sulfate pellets and demineralized bone matrix would prevent the establishment of infection in a contaminated fracture model. Published in The Journal of Bone & Joint Surgery, v87 n1 p107-112, Jan 23005.