Persistence of Serogroup C Antibody Responses Following Quadrivalent Meningococcal Conjugate Vaccination in United States Military Personnel

Pre-vaccination rabbit serum bactericidal assay (rSBA) geometric mean titer (GMT) was less than 1:8 for the MenACWYD group. rSBA GMT increased to 703 at 5-7 months post-vaccination and decreased by 90% at 3 years post-vaccination. GMTs were significantly lower in the MenACWY(D) group at 11-13 and 17...

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Bibliographische Detailangaben
Hauptverfasser:	Patel, Manisha, Romero-Steiner, Sandra, Broderick, Michael P, Thomas, Cynthia G, Plikaytis, Brian D, Schmidt, Daniel S, Johnson, Scott E, Milton, Andrea S, Carlone, George M, Clark, Thomas A
Format:	Report
Sprache:	eng
Schlagworte:	ANTIBODIES BIOASSAY Biochemistry DEMOGRAPHY ENZYMES GEOMETRY GERMICIDES GMCS(GEOMETRIC MEAN CONCENTRATIONS) IMMUNIZATION INFECTIOUS DISEASES Medicine and Medical Research MENINGOCOCCAL DISEASES MENINGOCOCCAL VACCINE Military Forces and Organizations MILITARY MEDICINE MILITARY PERSONNEL NEISSERIA MENINGITIDIS OPTIMIZATION Pharmacology POLYSACCHARIDES PROTEINS(CONJUGATED) RESPONSE(BIOLOGY) STATISTICAL ANALYSIS TOLERANCES(PHYSIOLOGY) VACCINES
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Zusammenfassung:	Pre-vaccination rabbit serum bactericidal assay (rSBA) geometric mean titer (GMT) was less than 1:8 for the MenACWYD group. rSBA GMT increased to 703 at 5-7 months post-vaccination and decreased by 90% at 3 years post-vaccination. GMTs were significantly lower in the MenACWY(D) group at 11-13 and 17-19 months post-vaccination compared with the MPSV4 group. The percentage of MenACWY(D) recipients achieving a rSBA titer of greater than or equal to 1:8 decreased from 87% at 5-7 months to 54% at 3 years. There were no significant differences in the proportion of subjects with a titer of greater than or equal to1:8 at any time point between vaccine groups. Geometric mean concentrations (GMCs) decreased from 1.1 microng/mL at 5-7 months to 0.6 microng/mL at 3 years in the MenACWY(D) group and were significantly lower than GMCs in the MPSV4 group at all time points. Published in Vaccine, v32 p3805-3809, 14 May 2014. Sponsored in part by the Bureau of Medicine and Surgery, Falls Church, VA.