Structural, Morphological, and Functional Correlates of Corneal Endothelial Toxicity Following Corneal Exposure to Sulfur Mustard Vapor

Structural, Morphological, and Functional Correlates of Corneal Endothelial Toxicity Following Corneal Exposure to Sulfur Mustard Vapor

Sulfur mustard (SM) is a highly reactive vesicant that causes severe ocular injuries. Following exposure to moderate or high doses, a subset of victims develops a chronic injury known as mustard gas keratopathy (MGK) involving a keratitis of unknown etiopathogenesis with secondary keratopathies such...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: McNutt, Patrick M, Tuznik, Kaylie, Nelson, Marian, Adkins, Angie, Lyman, Megan, Glotfelty, Elliot, Hughes, James, Hamilton, Tracey
Format: Report
Sprache:eng
Schlagworte:
CORNEA
CORNEAL EDEMA
CORNEAL ENDOTHELIAL CELLS
DOSAGE
ENDOTHELIUM
EPITHELIUM
EXPOSURE(PHYSIOLOGY)
EYE
GASES
LESIONS
Medicine and Medical Research
Military Operations, Strategy and Tactics
MUSTARD AGENTS
MUSTARD GAS
MUSTARD GAS KERATOPATHY
REACTIVITIES
SULFUR
SULFUR MUSTARD
TOXICITY
VAPORS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Sulfur mustard (SM) is a highly reactive vesicant that causes severe ocular injuries. Following exposure to moderate or high doses, a subset of victims develops a chronic injury known as mustard gas keratopathy (MGK) involving a keratitis of unknown etiopathogenesis with secondary keratopathies such as persistent epithelial lesions, corneal neovascularization, and progressive corneal degeneration. This study was designed to determine whether SM exposure evokes acute endothelial toxicity and to determine whether endothelial pathologies were specifically observed in MGK corneas as opposed to healed corneas. The original document contains color images. Pub. in Investigative Ophthalmology & Visual Science, v54 n10, p6735 6744, 2013.