NR2B-N-Methyl-D-Aspartate Receptors Contribute to Network Asynchrony and Loss of Long-Term Potentiation Following Mild Mechanical Injury In Vitro

NR2B-N-Methyl-D-Aspartate Receptors Contribute to Network Asynchrony and Loss of Long-Term Potentiation Following Mild Mechanical Injury In Vitro

To understand how mechanical injury affects neural circuits, we (1) built a multi-scale stochastic integrate-and-fire model of network activity, (2) simulated an injured network, (3) predicted an important role for the NR2B-NMDA receptor in mediating network asynchrony, and 4) tested our predictions...

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Bibliographische Detailangaben
Hauptverfasser: Patel, Tapan P, Ventre, Scott C, Singh, Pallab K, Meaney, David F
Format: Report
Sprache:eng
Schlagworte:
Anatomy and Physiology
CIRCUITS
DENDRITIC SPINES
Electrical and Electronic Equipment
IN VITRO ANALYSIS
MECHANICAL PROPERTIES
Mechanics
NERVE CELLS
NETWORK ACTIVITIES
NETWORKS
NR2B-NMDA RECEPTORS
PE611103
SYNAPTIC TRANSMISSIONS
SYNCHRONY
TOPOLOGY
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Beschreibung
Zusammenfassung:To understand how mechanical injury affects neural circuits, we (1) built a multi-scale stochastic integrate-and-fire model of network activity, (2) simulated an injured network, (3) predicted an important role for the NR2B-NMDA receptor in mediating network asynchrony, and 4) tested our predictions using in vitro stretch injury