Pathogenesis of Acute and Delayed Corneal Lesions After Ocular Exposure to Sulfur Mustard Vapor

Sulfur mustard (SM) exposure results in dose-dependent morbidities caused by cytotoxicity and vesication. Although lesions resulting from ocular exposure often resolve clinically, an idiopathic delayed mustard gas keratopathy (MGK) can develop after a moderate or severe exposure. Sequelae include pe...

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Bibliographische Detailangaben
Hauptverfasser:	McNutt, Patrick, Hamilton, Tracey, Nelson, Marian, Adkins, Angela, Swartz, Adam, Lawrence, Richard, Milhorn, Denise
Format:	Report
Sprache:	eng
Schlagworte:	BLOOD VESSELS CHEMICAL WARFARE AGENTS Chemical, Biological and Radiological Warfare CORNEA CYTOTOXINS EXPOSURE(PHYSIOLOGY) GROWTH(PHYSIOLOGY) MEDICAL CHEMICAL DEFENSE Medicine and Medical Research MGK(MUSTARD GAS KERATOPATHY) MUSTARD AGENTS MUSTARD GAS KERATOPATHY OCULAR TOXICITY PATHOGENESIS SULFUR SULFUR MUSTARD Toxicology VAPOR EXPOSURE VAPORS VISION
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Beschreibung
Zusammenfassung:	Sulfur mustard (SM) exposure results in dose-dependent morbidities caused by cytotoxicity and vesication. Although lesions resulting from ocular exposure often resolve clinically, an idiopathic delayed mustard gas keratopathy (MGK) can develop after a moderate or severe exposure. Sequelae include persistent keratitis, recurring epithelial lesions, corneal neovascularization, and corneal degeneration, which can lead to impaired vision or loss of sight. The purpose of this effort is to correlate structural changes with injury progression during the development of MGK. The original document contains color images. Pub. in Cornea, v31 n3, p280-290, 2012.