Dose Response of Sodium Nitrite on Vasoactivity Associated with HBOC-201 in a Swine Model of Controlled Hemorrhage

Sodium nitrite (NaN02 ) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three lOml/kg infusions of either HBOC-201 or Hextend with and without NaNOr All vital signs, coagulation and blood chemistry were measured...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Arnaud, Francoise, Scultetus, Anke H, Kim, Bobby, Haque, Ashraful, Saha, Biswajit, Nigam, Savita, Moon-Massat, Paula, Auker, Charles, McCarron, Richard, Freilich, Daniel
Format:	Report
Sprache:	eng
Schlagworte:	BLOOD CHEMISTRY BLOOD PLATELETS BLOOD PRESSURE COAGULATION DOSAGE HEMORRHAGE INFUSIONS Medicine and Medical Research NITRIC OXIDE DONORS PRE-CLINICAL RESUSCITATION RESPONSE(BIOLOGY) SIGNS AND SYMPTOMS SODIUM NITRITE SWINE TRAUMA
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Sodium nitrite (NaN02 ) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three lOml/kg infusions of either HBOC-201 or Hextend with and without NaNOr All vital signs, coagulation and blood chemistry were measured for 2hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 micromol/kg NaN02 infusion. Complete abolition was obtained with the highest 3 NaN02 dose, but side effects were observed. There was no reduction in platelet function due to NaN Or NaN02 ability to reduce HBOC-201 vasoactivity was transient and 10.8 micromol/kg NaN02 seems an acceptable dose for further investigation. Pub. in Artificial Cells, Blood Substitutes, and Biotechnology, v39, p195-205, 2011.