Intravenous Perfluorocarbon After Onset of Decompression Sickness Decreases Mortality in 20-kg Swine
Decompression sickness (DCS) occurs when bubbles form due to pressure decreases with severity ranging from trivial to fatal. Standard treatment requires a hyperbaric chamber, not likely to be available at remote sites or during a disabled submarine escape or rescue. Alternative (non-recompressive) t...
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| creator | Mahon, Richard T Watanabe, Tomas T Wilson, Madison C Auker, Charles R |
| description | Decompression sickness (DCS) occurs when bubbles form due to pressure decreases with severity ranging from trivial to fatal. Standard treatment requires a hyperbaric chamber, not likely to be available at remote sites or during a disabled submarine escape or rescue. Alternative (non-recompressive) treatments are needed. Intravenous administration of emulsified perfluorocarbons (PFCs) enhances oxygen delivery to, and inert gas removal from, tissues. Swine studies show PFCs administered with supplemental oxygen before symptom onset can decrease DCS incidence. We used a swine model to test whether PFC plus supplemental oxygen could improve outcome when infused after DCS symptom onset.
Pub. in Aviation, Space, and Environmental Medicine, v81 n6, p555-559, Jun 2010. |
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Pub. in Aviation, Space, and Environmental Medicine, v81 n6, p555-559, Jun 2010.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | Biochemistry BLOOD DECOMPRESSION SICKNESS EMULSIONS ENDOTHELIUM FLUORINATED HYDROCARBONS GASES HYPERBARIC CHAMBERS INERT MATERIALS Medicine and Medical Research PERFLUOROCARBONS REMOTE AREAS REMOVAL Stress Physiology SUBMARINE ESCAPE SWINE TISSUES(BIOLOGY) VEINS |
| title | Intravenous Perfluorocarbon After Onset of Decompression Sickness Decreases Mortality in 20-kg Swine |
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