Intravenous Perfluorocarbon After Onset of Decompression Sickness Decreases Mortality in 20-kg Swine

Intravenous Perfluorocarbon After Onset of Decompression Sickness Decreases Mortality in 20-kg Swine

Decompression sickness (DCS) occurs when bubbles form due to pressure decreases with severity ranging from trivial to fatal. Standard treatment requires a hyperbaric chamber, not likely to be available at remote sites or during a disabled submarine escape or rescue. Alternative (non-recompressive) t...

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Bibliographische Detailangaben
Hauptverfasser: Mahon, Richard T, Watanabe, Tomas T, Wilson, Madison C, Auker, Charles R
Format: Report
Sprache:eng
Schlagworte:
Biochemistry
BLOOD
DECOMPRESSION SICKNESS
EMULSIONS
ENDOTHELIUM
FLUORINATED HYDROCARBONS
GASES
HYPERBARIC CHAMBERS
INERT MATERIALS
Medicine and Medical Research
PERFLUOROCARBONS
REMOTE AREAS
REMOVAL
Stress Physiology
SUBMARINE ESCAPE
SWINE
TISSUES(BIOLOGY)
VEINS
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Zusammenfassung:Decompression sickness (DCS) occurs when bubbles form due to pressure decreases with severity ranging from trivial to fatal. Standard treatment requires a hyperbaric chamber, not likely to be available at remote sites or during a disabled submarine escape or rescue. Alternative (non-recompressive) treatments are needed. Intravenous administration of emulsified perfluorocarbons (PFCs) enhances oxygen delivery to, and inert gas removal from, tissues. Swine studies show PFCs administered with supplemental oxygen before symptom onset can decrease DCS incidence. We used a swine model to test whether PFC plus supplemental oxygen could improve outcome when infused after DCS symptom onset. Pub. in Aviation, Space, and Environmental Medicine, v81 n6, p555-559, Jun 2010.