ED50 Study of Femtosecond Terawatt Laser Pulses on Porcine Skin

Terawatt (TW) lasers have become commonplace since the development of the chirped-pulse amplification method using Ti:sapphire and Nd:glass laser rods. We have measured the minimum visible lesion (MVL) thresholds for porcine1 (Yucatan minipig) skin using TW laser pulses. Our system produced laser pu...

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Hauptverfasser:	Kumru, Semih S, Cain, Clarence P, Noojin, Gary D, Cooper, Mary F, Imholte, Michelle L, Stolarski, David J, Cox, Duane D, Crane, Carrie C, Rockwell, Benjamin A
Format:	Report
Sprache:	eng
Schlagworte:	ABLATION ANESTHESIA Biochemistry DERMATOLOGY FEMTOSECOND LASER PULSES FEMTOSECOND TERAAWATT FILAMENTS FOCUSING GLASS LASERS LASER BEAMS LASER DAMAGE LASER INDUCED BREAKDOWN Lasers and Masers LESIONS MINI-PIG PE062202F PULSED LASERS RODS SAPPHIRE SELF OPERATION SWINE THRESHOLD EFFECTS ULTRASHORT PULSES VISIBILITY WUAFRL7757B226
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Zusammenfassung:	Terawatt (TW) lasers have become commonplace since the development of the chirped-pulse amplification method using Ti:sapphire and Nd:glass laser rods. We have measured the minimum visible lesion (MVL) thresholds for porcine1 (Yucatan minipig) skin using TW laser pulses. Our system produced laser pulses at 810 nm and sub-50 femtoseconds. These 1-2 TW laser pulses created multiple self-focusing (SF) filaments during propagation and were directed on the flanks of mini-pigs under anesthesia. We measured the pulse energies necessary to determine the ED50 skin damage thresholds. The original document contains color images. Pub. in Lasers in Surgery and Medicine, v37, p59-63, 2005.