An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement
The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI...
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| creator | Menard, Cynthia Susil, Robert C Choyke, Peter Coleman, Jonathan Grubb, Robert Gharib, Ahmed Krieger, Axel Guion, Peter Thomasson, David Ullman, Karen Gupta, Sandeep Espina, Virginia Liotta, Lance Petricoin, Emanuel Fitchtinger, Gabor Whitcomb, Louis L Atalar, Ergin Coleman, C N Camphausen, Kevin |
| description | The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer. |
| format | Report |
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Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer.</description><language>eng</language><subject>ANGIOGENESIS ; BIOPSY ; CONTRAST ; DCE-MRI(DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING) ; GENES ; Genetic Engineering and Molecular Biology ; GENOMES ; GENOMIC PROFILES ; HETEROGENEITY ; MAGNETIC RESONANCE IMAGING ; Medicine and Medical Research ; MICROANALYSIS ; MICROARRAY ANALYSIS ; MICROVASCULAR ; MOLECULAR BIOLOGY ; MOLECULAR IMAGING ; NEEDLE BIOPSY ; NONINVASIVE IMAGING ; OPTIMIZATION ; PATIENTS ; PERFUSION ; PERMEABILITY ; PROSTATE CANCER ; PROTEINS ; PROTEOMIC PROFILES ; SIGNAL INTENSITY ; TISSUES(BIOLOGY)</subject><creationdate>2004</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27565,27566</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA511673$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Menard, Cynthia</creatorcontrib><creatorcontrib>Susil, Robert C</creatorcontrib><creatorcontrib>Choyke, Peter</creatorcontrib><creatorcontrib>Coleman, Jonathan</creatorcontrib><creatorcontrib>Grubb, Robert</creatorcontrib><creatorcontrib>Gharib, Ahmed</creatorcontrib><creatorcontrib>Krieger, Axel</creatorcontrib><creatorcontrib>Guion, Peter</creatorcontrib><creatorcontrib>Thomasson, David</creatorcontrib><creatorcontrib>Ullman, Karen</creatorcontrib><creatorcontrib>Gupta, Sandeep</creatorcontrib><creatorcontrib>Espina, Virginia</creatorcontrib><creatorcontrib>Liotta, Lance</creatorcontrib><creatorcontrib>Petricoin, Emanuel</creatorcontrib><creatorcontrib>Fitchtinger, Gabor</creatorcontrib><creatorcontrib>Whitcomb, Louis L</creatorcontrib><creatorcontrib>Atalar, Ergin</creatorcontrib><creatorcontrib>Coleman, C N</creatorcontrib><creatorcontrib>Camphausen, Kevin</creatorcontrib><creatorcontrib>JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE</creatorcontrib><title>An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement</title><description>The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer.</description><subject>ANGIOGENESIS</subject><subject>BIOPSY</subject><subject>CONTRAST</subject><subject>DCE-MRI(DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING)</subject><subject>GENES</subject><subject>Genetic Engineering and Molecular Biology</subject><subject>GENOMES</subject><subject>GENOMIC PROFILES</subject><subject>HETEROGENEITY</subject><subject>MAGNETIC RESONANCE IMAGING</subject><subject>Medicine and Medical Research</subject><subject>MICROANALYSIS</subject><subject>MICROARRAY ANALYSIS</subject><subject>MICROVASCULAR</subject><subject>MOLECULAR BIOLOGY</subject><subject>MOLECULAR IMAGING</subject><subject>NEEDLE BIOPSY</subject><subject>NONINVASIVE IMAGING</subject><subject>OPTIMIZATION</subject><subject>PATIENTS</subject><subject>PERFUSION</subject><subject>PERMEABILITY</subject><subject>PROSTATE CANCER</subject><subject>PROTEINS</subject><subject>PROTEOMIC PROFILES</subject><subject>SIGNAL INTENSITY</subject><subject>TISSUES(BIOLOGY)</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2004</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFjbEKwkAQRNNYiPoHFvsDKUJQ65BEkiIgkj4s58Y7uOzi3UXQyk_3AvZWwzDzZtbJp2BoOZB7EgcjjBa6aws9Kc3mMROM4iBogk4sqdmig1KjQxUR88YFARmhoejlTkwy-2XQYXpx4kNsKKhejFPUUpbAB6hZIyua4uc2WY1oPe1-ukn257ovm_QWycEHwxSGoioOWXY85fmf-AtOBUaG</recordid><startdate>200410</startdate><enddate>200410</enddate><creator>Menard, Cynthia</creator><creator>Susil, Robert C</creator><creator>Choyke, Peter</creator><creator>Coleman, Jonathan</creator><creator>Grubb, Robert</creator><creator>Gharib, Ahmed</creator><creator>Krieger, Axel</creator><creator>Guion, Peter</creator><creator>Thomasson, David</creator><creator>Ullman, Karen</creator><creator>Gupta, Sandeep</creator><creator>Espina, Virginia</creator><creator>Liotta, Lance</creator><creator>Petricoin, Emanuel</creator><creator>Fitchtinger, Gabor</creator><creator>Whitcomb, Louis L</creator><creator>Atalar, Ergin</creator><creator>Coleman, C N</creator><creator>Camphausen, Kevin</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>200410</creationdate><title>An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement</title><author>Menard, Cynthia ; 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Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ANGIOGENESIS BIOPSY CONTRAST DCE-MRI(DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING) GENES Genetic Engineering and Molecular Biology GENOMES GENOMIC PROFILES HETEROGENEITY MAGNETIC RESONANCE IMAGING Medicine and Medical Research MICROANALYSIS MICROARRAY ANALYSIS MICROVASCULAR MOLECULAR BIOLOGY MOLECULAR IMAGING NEEDLE BIOPSY NONINVASIVE IMAGING OPTIMIZATION PATIENTS PERFUSION PERMEABILITY PROSTATE CANCER PROTEINS PROTEOMIC PROFILES SIGNAL INTENSITY TISSUES(BIOLOGY) |
| title | An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement |
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