An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement

An Interventional MRI Technique for the Molecular Characterization of Heterogeneous Intra-Prostatic Dynamic Contrast Enhancement

The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI...

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Bibliographische Detailangaben
Hauptverfasser: Menard, Cynthia, Susil, Robert C, Choyke, Peter, Coleman, Jonathan, Grubb, Robert, Gharib, Ahmed, Krieger, Axel, Guion, Peter, Thomasson, David, Ullman, Karen, Gupta, Sandeep, Espina, Virginia, Liotta, Lance, Petricoin, Emanuel, Fitchtinger, Gabor, Whitcomb, Louis L, Atalar, Ergin, Coleman, C N, Camphausen, Kevin
Format: Report
Sprache:eng
Schlagworte:
ANGIOGENESIS
BIOPSY
CONTRAST
DCE-MRI(DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING)
GENES
Genetic Engineering and Molecular Biology
GENOMES
GENOMIC PROFILES
HETEROGENEITY
MAGNETIC RESONANCE IMAGING
Medicine and Medical Research
MICROANALYSIS
MICROARRAY ANALYSIS
MICROVASCULAR
MOLECULAR BIOLOGY
MOLECULAR IMAGING
NEEDLE BIOPSY
NONINVASIVE IMAGING
OPTIMIZATION
PATIENTS
PERFUSION
PERMEABILITY
PROSTATE CANCER
PROTEINS
PROTEOMIC PROFILES
SIGNAL INTENSITY
TISSUES(BIOLOGY)
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Zusammenfassung:The biological characterization of an individual patient's tumor by non-invasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of MRI contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely co-localizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patient with prostate cancer.