The Sensitivities of Yeast Strains Deficient in PDR ABC Transporters to Quinoline-Ring Antimalarial Drugs

Data indicate a potential role for the Pdr5p P-glycoprotein ATP-binding-cassette (ABC) transporter in mediating chloroquine sensitivity in S. cervisae. This is consistent with the hypothesis that such a transporter plays a role in mediating quinoline-drug resistance in P. falciparum, and complements...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Emerson, Lyndal R, Skillman, Bradley C, Wolfger, H, Kuchler, K, Wirth, D F
Format:	Report
Sprache:	eng
Schlagworte:	ABC(ATP-BINDING-CASSETTE) TRANSPORTERS CHLOROQUINE CYCLOHEXIMIDE MALARIA MDR(MULTI-DRUG RESISTANCE) Medicine and Medical Research PDR(PLEIOTROPIC DRUG RESISTANCE) PLASMODIUM FALCIPARUM QUINOLINES REPRINTS RESISTANCE SENSITIVITY YEASTS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Data indicate a potential role for the Pdr5p P-glycoprotein ATP-binding-cassette (ABC) transporter in mediating chloroquine sensitivity in S. cervisae. This is consistent with the hypothesis that such a transporter plays a role in mediating quinoline-drug resistance in P. falciparum, and complements the results of previous studies on the parasite. Additional gene products also play a major role in mediating chloroquine sensitivity and resistance, apparently through the modulation of vacuolar pH in the parasite. Pub. in Annals of Tropical Medicine and Parasitology, v98 n6 p643-649, 2004.