Perioperative Closed-Loop Control of Analgesia in Humans

We present a new paradigm for intraoperative closed-loop control of analgesia in humans. The infusion rate of the opiate alfentanil is the manipulated variable which is administered intravenously through a Computer Controlled Infusion Pump (CCIP), The two regulated outputs are the patient's Mea...

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Bibliographische Detailangaben
Hauptverfasser:	Schaniel, Christoph, Gentilini, Andrea, Morari, Manfred, Bieniok, Christian, Wymann, Rolf
Format:	Report
Sprache:	eng
Schlagworte:	ALFENTANIL ANALGESIA ARTERIES BLOOD PRESSURE CCIP(COMPUTER CONTROLLED INFUSION PUMP) CLOSED LOOP SYSTEMS FOREIGN REPORTS HUMANS MAP(MEAN ARTERIAL PRESSURE) MPC(MODEL PREDICTIVE CONTROL) OPIUM ALKALOIDS PAIN PARENTERAL INFUSIONS Pharmacology SURGERY SWITZERLAND SYMPOSIA TITRATION
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Beschreibung
Zusammenfassung:	We present a new paradigm for intraoperative closed-loop control of analgesia in humans. The infusion rate of the opiate alfentanil is the manipulated variable which is administered intravenously through a Computer Controlled Infusion Pump (CCIP), The two regulated outputs are the patient's Mean Arterial Pressure (MAP) and the drug concentration in the plasma. Papers from 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 25-28, 2001, held in Istanbul, Turkey. See also ADM001351 for entire conference on cd-rom., The original document contains color images. Prepared in cooperation with Dept. of Anesthesiology, Inselspital, Bern, Switzerland.