Antibodies to Anthrax Toxin in Humans and Guinea Pigs and Their Relevance to Protective Immunity

Antibodies to Anthrax Toxin in Humans and Guinea Pigs and Their Relevance to Protective Immunity

A forerunning study on the relationship between antibodies to the protective antigen (PA) and lethal factor (LF) components of anthrax toxin and protective immunity has been expanded and extended to include the third toxin component, the edema factor (EF). It was found that protection against the va...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Turnbull, P C, Leppla, S H, Broster, M G, Quinn, C P, Melling, J
Format: Report
Sprache:eng
Schlagworte:
ANTHRAX
ANTIBODIES
ANTIGENS
BACILLUS ANTHRACIS
BACTERIAL TOXINS
EDEMA
FOREIGN REPORTS
GUINEA PIGS
HUMANS
IMMUNITY
LETHALITY
Medicine and Medical Research
PRODUCTION
STIMULATION(GENERAL)
Toxicology
TOXINS AND ANTITOXINS
VACCINES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A forerunning study on the relationship between antibodies to the protective antigen (PA) and lethal factor (LF) components of anthrax toxin and protective immunity has been expanded and extended to include the third toxin component, the edema factor (EF). It was found that protection against the vaccine resistant Ames strain was possible in the absence of detectable anti-LF and anti-EF antibodies. Evidence is given that PA may be the essential anthrax-derived antigen for protection, but that equally essential is that it be presented to the host 5 immune system in such a manner as to provide stimulation of more than just production of antibody to PA. Titers to the three components in sera of individuals with histories of clinically diagnosed anthrax as well as from human vaccinees are included in the report.