Effects of Sodium 2-Mercaptoethanesulfonate (Mesna) as a Post-Treatment in Mice Challenged With Phosgene

The effects of 2-mercaptoethanesulfonate (mesna) as a post-treatment against exposure to a lethal dose of phosgene (CG) were investigated. Mesna appears to be a potential candidate against phosgene-induced injury because it may increase sulfhydryl concentrations, which may reduce cellular injury. Mi...

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Hauptverfasser:	Forster, Jeffry S, Baskin, Steven I, Moran, Theodore S, Cascio, Mathew P, Sciuto, Alfred M
Format:	Report
Sprache:	eng
Schlagworte:	ANTIOXIDANTS Chemical, Biological and Radiological Warfare CHEMOTHERAPEUTIC AGENTS DRUGS EDEMA EXPOSURE(PHYSIOLOGY) LETHAL DOSAGE LUNG MESNA(2-MERCAPTOETHANESULFONATE) MICE PE63384A Pharmacology PHOSGENE PHOSPHATES PROTEINS THIOLS TOXICITY
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Zusammenfassung:	The effects of 2-mercaptoethanesulfonate (mesna) as a post-treatment against exposure to a lethal dose of phosgene (CG) were investigated. Mesna appears to be a potential candidate against phosgene-induced injury because it may increase sulfhydryl concentrations, which may reduce cellular injury. Mice were exposed to phosgene, 32 mg/m(3) , or air for 20 minutes. After a 5-minute washout with air, mice were injected interperitoneally (ip) with 0, 334, 834 or 1,667 mg/kg of mesna or phosphate buffered saline (PBS) at 20 minutes, 2, 5, 8 and 11 hours. Survival was assessed every 2 hours for 12 hours and at 24 hours. Lungs were removed and analyzed for wet weight, dry weight, wet/dry ratio, protein, and non-protein sulfhydryls (NPSH).