Evaluation of the Vesicating Properties of Neutralized Chemical Agent Identification Set (CAIS) Components

Vesication and skin irritation studies were conducted in hairless guinea pigs to ascertain the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). CAIS are training items that contain agent (HD, HN, or L) and were declared obsolete in 1971. Ani...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Olson, Carl T, Hayes, Timothy L, Singer, Allen W, Menton, Ronald G, Kiser, Robyn C
Format:	Report
Sprache:	eng
Schlagworte:	3-DICHLORO-5 5-DIMETHYLHYDANTOIN ACUTE TOXICITY(DERMAL) ANIMALS CAIS(CHEMICAL AGENT IDENTIFICATION SET) CHARCOAL CHEMICAL AGENTS CHEMICAL ANALYSIS Chemical, Biological and Radiological Warfare CHLORINE CHLOROFORM DCDMH EDEMA ERYTHEMA GUINEA PIGS HD AGENT HISTOPATHOLOGY HN AGENT HYDANTOINS IDENTIFICATION IRRITATING AGENTS L AGENT LESIONS LEWISITE METHYL RADICALS MICROBLISTERS MICROVESICATION MUSTARD AGENTS NEUTRALIZATION RRS(RAPID ROSPONSE SYSTEM) SKIN(ANATOMY) SOLUTIONS(MIXTURES) TOXICITY VESICANTS WASTESTREAMS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Vesication and skin irritation studies were conducted in hairless guinea pigs to ascertain the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). CAIS are training items that contain agent (HD, HN, or L) and were declared obsolete in 1971. Animals were dosed with 'test article' EITHER NEAT HD, 10% agent/chloroform solutions or product solutions (wastestreams) and evaluated for skin-damaging effects (gross and light microscopic). Product solutions from the chemical neutralization of CAIS (either agent/chloroform or agent/charcoal) produced no microblisters. Dermal application of product solutions from the neutralization of neat HD resulted in microvesicle formation (vesication). All agent-dosed (either agent/chloroform solutions or HD) sites exhibited micro- blisters as well as other histopathologic lesions. Skin irritant effects were consistent with the skin-injurious activity (erythema and edema) associated with the neutralizing reagent 1 ,3-DICHLORO-5,5-DIMETHYLHYDANTOIN (DCDMH).