Evaluation of N-Methyl-n'-Nitroguanidine in Short-Term Genetic Toxicity Tests

N-Methyl-N'-nitroguanidine (MNG) is being considered as a component of Air Force explosive formulations. This chemical was evaluated in several bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonella/microsomal assay, the Chinese hamster ovary/hypoxan...

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Hauptverfasser:	Godin, C S, Thilagar, A
Format:	Report
Sprache:	eng
Schlagworte:	ACTIVATION AIR AIR FORCE AIR FORCE RESEARCH BONE MARROW BONES CHEMICALS ENZYMES EXPLOSIVES FORMULATIONS GENETICS GUANINE HAMSTERS IN VITRO ANALYSIS MATERIALS Medicine and Medical Research MNG(N-METHYL N NITROGUANIDINE) MUTATIONS NITROGUANIDINE OVARIES PE62202F RISK SALMONELLA SALMONELLA TYPHIMURIUM TEST AND EVALUATION TOXICITY Toxicology WUAL63020174
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Zusammenfassung:	N-Methyl-N'-nitroguanidine (MNG) is being considered as a component of Air Force explosive formulations. This chemical was evaluated in several bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonella/microsomal assay, the Chinese hamster ovary/hypoxanthine- guanine phosphoribosyltransferase forward mutation assay, and the mouse in vivo bone marrow micronucleus assay. Both in vitro assays were conducted in the presence and absence of S9 metabolic activation enzymes. The results of the three genetic tests indicated that MNG does not interact with genetic material. Also, no toxicity was observed for very high dose levels. These assays would therefore predict essentially no genotoxic risk from exposure to MNG. Ames Assay, Forward Mutation Assay, Genotoxicity, N-Methyl-N'-Nitroguanidine, Mouse Micronucleus Assay.