The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident
Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base ex...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Report |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | White, Vicky L Canfield, Dennis V Hordinsky, Jerry R |
| description | Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography. |
| format | Report |
| fullrecord | <record><control><sourceid>dtic_1RU</sourceid><recordid>TN_cdi_dtic_stinet_ADA255936</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ADA255936</sourcerecordid><originalsourceid>FETCH-dtic_stinet_ADA2559363</originalsourceid><addsrcrecordid>eNqFjLsKAjEQRdNYiPoHFvMD27isYBl1Fy2FWC9DMsGBbAKz4_8bH73VhXMPZ2mCexBcA2XlyB6VSwbMAW5PrEi_oERwwjgpCWUCznBMpYSPeBeuKEqZAGFAxQSWxQtGBes9v9Nrs4iYZtr8dmW2Q-9OlyYo-3HWWtDRnu2u6w7tvv1zvwDtRDrY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>report</recordtype></control><display><type>report</type><title>The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident</title><source>DTIC Technical Reports</source><creator>White, Vicky L ; Canfield, Dennis V ; Hordinsky, Jerry R</creator><creatorcontrib>White, Vicky L ; Canfield, Dennis V ; Hordinsky, Jerry R ; FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE</creatorcontrib><description>Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography.</description><language>eng</language><subject>ACCIDENTS ; AIRCRAFT ; Anatomy and Physiology ; AVIATION ACCIDENTS ; BLOOD ; CHROMATOGRAPHY ; DIURETICS ; DRUGS ; EFFICIENCY ; EXTRACTION ; GAS CHROMATOGRAPHY ; HPLC ; HYPERTENSION ; IDENTIFICATION ; LAYERS ; LIQUID CHROMATOGRAPHY ; LIQUIDS ; Military Aircraft Operations ; Pharmacology ; REGIONS ; SOLVENTS ; TLC ; TRIAMTERENE</subject><creationdate>1992</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,780,885,27566,27567</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA255936$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>White, Vicky L</creatorcontrib><creatorcontrib>Canfield, Dennis V</creatorcontrib><creatorcontrib>Hordinsky, Jerry R</creatorcontrib><creatorcontrib>FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE</creatorcontrib><title>The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident</title><description>Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography.</description><subject>ACCIDENTS</subject><subject>AIRCRAFT</subject><subject>Anatomy and Physiology</subject><subject>AVIATION ACCIDENTS</subject><subject>BLOOD</subject><subject>CHROMATOGRAPHY</subject><subject>DIURETICS</subject><subject>DRUGS</subject><subject>EFFICIENCY</subject><subject>EXTRACTION</subject><subject>GAS CHROMATOGRAPHY</subject><subject>HPLC</subject><subject>HYPERTENSION</subject><subject>IDENTIFICATION</subject><subject>LAYERS</subject><subject>LIQUID CHROMATOGRAPHY</subject><subject>LIQUIDS</subject><subject>Military Aircraft Operations</subject><subject>Pharmacology</subject><subject>REGIONS</subject><subject>SOLVENTS</subject><subject>TLC</subject><subject>TRIAMTERENE</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1992</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFjLsKAjEQRdNYiPoHFvMD27isYBl1Fy2FWC9DMsGBbAKz4_8bH73VhXMPZ2mCexBcA2XlyB6VSwbMAW5PrEi_oERwwjgpCWUCznBMpYSPeBeuKEqZAGFAxQSWxQtGBes9v9Nrs4iYZtr8dmW2Q-9OlyYo-3HWWtDRnu2u6w7tvv1zvwDtRDrY</recordid><startdate>199207</startdate><enddate>199207</enddate><creator>White, Vicky L</creator><creator>Canfield, Dennis V</creator><creator>Hordinsky, Jerry R</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>199207</creationdate><title>The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident</title><author>White, Vicky L ; Canfield, Dennis V ; Hordinsky, Jerry R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA2559363</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1992</creationdate><topic>ACCIDENTS</topic><topic>AIRCRAFT</topic><topic>Anatomy and Physiology</topic><topic>AVIATION ACCIDENTS</topic><topic>BLOOD</topic><topic>CHROMATOGRAPHY</topic><topic>DIURETICS</topic><topic>DRUGS</topic><topic>EFFICIENCY</topic><topic>EXTRACTION</topic><topic>GAS CHROMATOGRAPHY</topic><topic>HPLC</topic><topic>HYPERTENSION</topic><topic>IDENTIFICATION</topic><topic>LAYERS</topic><topic>LIQUID CHROMATOGRAPHY</topic><topic>LIQUIDS</topic><topic>Military Aircraft Operations</topic><topic>Pharmacology</topic><topic>REGIONS</topic><topic>SOLVENTS</topic><topic>TLC</topic><topic>TRIAMTERENE</topic><toplevel>online_resources</toplevel><creatorcontrib>White, Vicky L</creatorcontrib><creatorcontrib>Canfield, Dennis V</creatorcontrib><creatorcontrib>Hordinsky, Jerry R</creatorcontrib><creatorcontrib>FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>White, Vicky L</au><au>Canfield, Dennis V</au><au>Hordinsky, Jerry R</au><aucorp>FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident</btitle><date>1992-07</date><risdate>1992</risdate><abstract>Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_dtic_stinet_ADA255936 |
| source | DTIC Technical Reports |
| subjects | ACCIDENTS AIRCRAFT Anatomy and Physiology AVIATION ACCIDENTS BLOOD CHROMATOGRAPHY DIURETICS DRUGS EFFICIENCY EXTRACTION GAS CHROMATOGRAPHY HPLC HYPERTENSION IDENTIFICATION LAYERS LIQUID CHROMATOGRAPHY LIQUIDS Military Aircraft Operations Pharmacology REGIONS SOLVENTS TLC TRIAMTERENE |
| title | The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A18%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-dtic_1RU&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.btitle=The%20Identification%20and%20Quantitation%20of%20Triamterene%20in%20Blood%20and%20Urine%20from%20a%20Fatal%20Aircraft%20Accident&rft.au=White,%20Vicky%20L&rft.aucorp=FEDERAL%20AVIATION%20ADMINISTRATION%20WASHINGTON%20DC%20OFFICE%20OF%20AVIATION%20MEDICINE&rft.date=1992-07&rft_id=info:doi/&rft_dat=%3Cdtic_1RU%3EADA255936%3C/dtic_1RU%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |