The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident

Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base ex...

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Hauptverfasser:	White, Vicky L, Canfield, Dennis V, Hordinsky, Jerry R
Format:	Report
Sprache:	eng
Schlagworte:	ACCIDENTS AIRCRAFT Anatomy and Physiology AVIATION ACCIDENTS BLOOD CHROMATOGRAPHY DIURETICS DRUGS EFFICIENCY EXTRACTION GAS CHROMATOGRAPHY HPLC HYPERTENSION IDENTIFICATION LAYERS LIQUID CHROMATOGRAPHY LIQUIDS Military Aircraft Operations Pharmacology REGIONS SOLVENTS TLC TRIAMTERENE
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Zusammenfassung:	Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography.