Ultrasound Assisted Assay for Toxins in Blood. SBIR 90.I (A90-180)

Work was carried out to determine the feasibility for a spectroscopic analysis of saxitoxin in whole blood samples. Modifications of standard chemical assays were to be used in conjunction with TRA's ultrasonic blood separation technology to form an analytical detection system that is suitable...

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Bibliographische Detailangaben
Hauptverfasser:	Baker, Charles D, Sanders, Clifton G, Borromeo, Peter
Format:	Report
Sprache:	eng
Schlagworte:	Anatomy and Physiology Biochemistry BLOOD BLOOD CIRCULATION BLOOD PLASMA CHEMICALS CHOLESTEROL CHOLESTEROL OXIDASE SYSTEM DETECTION FEASIBILITY STUDIES FLUOROMETERS FORMULATIONS INTERFERENCE Medicine and Medical Research MODIFICATION OXIDATION OXIDIZERS PE65502A PERSONNEL PHASE RA1 SAXITOXIN SBIR REPORTS SBIR(SMALL BUSINESS INNOVATION RESEARCH) SEPARATION SOLIDS ULTRASONICS WORK WU271 WUDA346103
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Beschreibung
Zusammenfassung:	Work was carried out to determine the feasibility for a spectroscopic analysis of saxitoxin in whole blood samples. Modifications of standard chemical assays were to be used in conjunction with TRA's ultrasonic blood separation technology to form an analytical detection system that is suitable for field use by minimally trained personnel. The chemical assay method was successfully to generate a fluorescent saxitoxin derivative using solid oxidants in a stable dry formulation. Direct detection of low levels of this analyte in plasma was precluded by interference from the plasma matrix. Chemical Assay, Oxidants, Spectroscopic Detection, RAI, SBIR Phase I, Ultrasound, Fluorimetry.