Epidemiology and Control of Malaria, Leishmaniasis and Schistosomiasis

Compounds were screened for activity against S. mansoni and data were forwarded to Division of Experimental Therapeutics, WRAIR, for analysis. A new mouse colony was initiated with fresh stock from WRAIR. In leishmaniasis studies, field collections of sandflies were made, and over 3000 sandflies were dissected for species determination and for detection of infections. Three non- leishmanial flagellates were found. Reservoir host studies resulted in a sixth isolate from Proechimvs iheringi. It, like the others, was closely related to L. mexicana amazonensis. In a malaria epidemiology project, initial physical examinations were made and medical records initiated on about 1000 people, representing one-third of the population of Costa Marques, and initial mosquitoes survey were made to determine vector species present and to locate breeding sites. Sera were collected to study prevalence of anti-sporozoite antibodies. Keywords: Lab animals; Hamsters; Mice; Brazil; Schistosomiasis; Chemotherapy; Drug development.