Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs
The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes rep...
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| creator | LeTellier, Yvonne C Brown, Larry D Korte, Jr, Don W |
| description | The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition. |
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DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition.</description><language>eng</language><subject>Ammunition and Explosives ; BUEHLER TEST ; DEPARTMENT OF DEFENSE ; ETHYLENE GLYCOL ; FORMULATIONS(CHEMISTRY) ; GUINEA PIGS ; MALES ; MAMMALIAN TOXICOLOGY ; MAMMALS ; NITRATES ; NITROGLYCERIN ; PE62720A ; SENSITIVITY ; SKIN(ANATOMY) ; SOLID PROPELLANTS ; TEST AND EVALUATION ; TOXICITY ; Toxicology ; WUDA303913</subject><creationdate>1989</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,776,881,27544,27545</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA215151$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LeTellier, Yvonne C</creatorcontrib><creatorcontrib>Brown, Larry D</creatorcontrib><creatorcontrib>Korte, Jr, Don W</creatorcontrib><creatorcontrib>LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA</creatorcontrib><title>Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs</title><description>The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition.</description><subject>Ammunition and Explosives</subject><subject>BUEHLER TEST</subject><subject>DEPARTMENT OF DEFENSE</subject><subject>ETHYLENE GLYCOL</subject><subject>FORMULATIONS(CHEMISTRY)</subject><subject>GUINEA PIGS</subject><subject>MALES</subject><subject>MAMMALIAN TOXICOLOGY</subject><subject>MAMMALS</subject><subject>NITRATES</subject><subject>NITROGLYCERIN</subject><subject>PE62720A</subject><subject>SENSITIVITY</subject><subject>SKIN(ANATOMY)</subject><subject>SOLID PROPELLANTS</subject><subject>TEST AND EVALUATION</subject><subject>TOXICITY</subject><subject>Toxicology</subject><subject>WUDA303913</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>1989</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNrjZPB0SS3KTcxRCE7NK84syaxKLMnMz1MIyC9JzSvJBIrnpym4eLr76AYFKATn52SmKAQU5Rek5uQk5pUoZOYpuJdm5qUmKgRkphfzMLCmJeYUp_JCaW4GGTfXEGcP3ZSSzOT44hKgwpJ4RxdHI0NTIDQmIA0AV1Uwhg</recordid><startdate>198910</startdate><enddate>198910</enddate><creator>LeTellier, Yvonne C</creator><creator>Brown, Larry D</creator><creator>Korte, Jr, Don W</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>198910</creationdate><title>Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs</title><author>LeTellier, Yvonne C ; Brown, Larry D ; Korte, Jr, Don W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA2151513</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Ammunition and Explosives</topic><topic>BUEHLER TEST</topic><topic>DEPARTMENT OF DEFENSE</topic><topic>ETHYLENE GLYCOL</topic><topic>FORMULATIONS(CHEMISTRY)</topic><topic>GUINEA PIGS</topic><topic>MALES</topic><topic>MAMMALIAN TOXICOLOGY</topic><topic>MAMMALS</topic><topic>NITRATES</topic><topic>NITROGLYCERIN</topic><topic>PE62720A</topic><topic>SENSITIVITY</topic><topic>SKIN(ANATOMY)</topic><topic>SOLID PROPELLANTS</topic><topic>TEST AND EVALUATION</topic><topic>TOXICITY</topic><topic>Toxicology</topic><topic>WUDA303913</topic><toplevel>online_resources</toplevel><creatorcontrib>LeTellier, Yvonne C</creatorcontrib><creatorcontrib>Brown, Larry D</creatorcontrib><creatorcontrib>Korte, Jr, Don W</creatorcontrib><creatorcontrib>LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LeTellier, Yvonne C</au><au>Brown, Larry D</au><au>Korte, Jr, Don W</au><aucorp>LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs</btitle><date>1989-10</date><risdate>1989</risdate><abstract>The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition.</abstract><oa>free_for_read</oa></addata></record> |
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| source | DTIC Technical Reports |
| subjects | Ammunition and Explosives BUEHLER TEST DEPARTMENT OF DEFENSE ETHYLENE GLYCOL FORMULATIONS(CHEMISTRY) GUINEA PIGS MALES MAMMALIAN TOXICOLOGY MAMMALS NITRATES NITROGLYCERIN PE62720A SENSITIVITY SKIN(ANATOMY) SOLID PROPELLANTS TEST AND EVALUATION TOXICITY Toxicology WUDA303913 |
| title | Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs |
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