Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs

Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs

The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes rep...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: LeTellier, Yvonne C, Brown, Larry D, Korte, Jr, Don W
Format: Report
Sprache:eng
Schlagworte:
Ammunition and Explosives
BUEHLER TEST
DEPARTMENT OF DEFENSE
ETHYLENE GLYCOL
FORMULATIONS(CHEMISTRY)
GUINEA PIGS
MALES
MAMMALIAN TOXICOLOGY
MAMMALS
NITRATES
NITROGLYCERIN
PE62720A
SENSITIVITY
SKIN(ANATOMY)
SOLID PROPELLANTS
TEST AND EVALUATION
TOXICITY
Toxicology
WUDA303913
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition.