Dermal Sensitization Potential of Trimethylolethane Trinitrate (TMETN) in Guinea Pigs

The Department of Defense is considering the use of either diethyleneglycol dinitrate (DEGDN), triethyleneglycol dinitrate (TEGDN), or trimethylolethane trinitrate (TMETN) as a replacement for nitroglycerin in new propellant formulations. Trimethylolethane trinitrate (TMETN) was evaluated for its po...

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Bibliographische Detailangaben
Hauptverfasser:	LeTellier, Yvonne C, Brown, L D, Korte, D W
Format:	Report
Sprache:	eng
Schlagworte:	BUEHLER TEST DEPARTMENT OF DEFENSE ETHANES ETHYLENE ETHYLENE GLYCOL FORMULATIONS(CHEMISTRY) GLYCOLS GUINEA PIGS Holography HYDROXYL RADICALS MALES METHYL RADICALS NITRATE(TRI)/TRIMETHYLOLETHANE NITRATES NITROGLYCERIN PE62720A PROPELLANTS SENSITIVITY SKIN(ANATOMY) TEST AND EVALUATION TMETN TMETN(TRIMETHYLOLETHANE TRINITRATE) Toxicology TRIMETHYLOLETHANE TRINITRATE WUDA303913
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Beschreibung
Zusammenfassung:	The Department of Defense is considering the use of either diethyleneglycol dinitrate (DEGDN), triethyleneglycol dinitrate (TEGDN), or trimethylolethane trinitrate (TMETN) as a replacement for nitroglycerin in new propellant formulations. Trimethylolethane trinitrate (TMETN) was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence of TMETN-induced sensitization was obtained in the study.