Hyperthermia Impairs Retention of an Overtrained Spatial Task in the Morris Water Maze

Hyperthermia Impairs Retention of an Overtrained Spatial Task in the Morris Water Maze

Fifteen rats were trained to learn the location of a spatially fixed platform hidden in a Morris water maze (40 + or - 2 C). Then retention of the spatial task was assessed immediately after raising core body temperature (T sub c) to 42, 40 or 37 C (the normothermic control). The hyperthermic treatm...

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Bibliographische Detailangaben
Hauptverfasser: Rauch, T M, Welch, D I, Gallego, L
Format: Report
Sprache:eng
Schlagworte:
ANIMALS
BODY TEMPERATURE
CORES
HYPERTHERMIA
MAPPING
PE61102A
PLATFORMS
Psychology
RATS
RECOVERY
RETENTION(PSYCHOLOGY)
SPATIAL DISTRIBUTION
STRATEGY
Stress Physiology
TRAINING
WUDA0C6122
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Zusammenfassung:Fifteen rats were trained to learn the location of a spatially fixed platform hidden in a Morris water maze (40 + or - 2 C). Then retention of the spatial task was assessed immediately after raising core body temperature (T sub c) to 42, 40 or 37 C (the normothermic control). The hyperthermic treatment order was counterbalanced according to a Latin-square design. Hyperthermia at 42 C T sub c significantly impaired the retention of spatial performance. Hyperthermic animals were cooled to normothermia (T sub c = 37 C) and spatial performance tested again. Recooling resulted in a complete recovery of spatial performance. These results demonstrate that hyperthermia-induced amnesia can be obtained on an overtrained spatial mapping strategy and recooling initiates recovery of spatial performance. Keywords: Retention psychology.