Mipafox as a Substrate for Rangia-DFPase

Mipafox as a Substrate for Rangia-DFPase

The effect of mipafox (N,N'-diisopropylphosphordiamidofluoridate) on the DFPase activity of clam digestive gland was investigated. An increasing trend in hydrolysis rates resulted where mipafox activity DFP activity DFP with mipafox activity. Mipafox is a known inhibitor of DFPase from hog'...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chester, Nancy A, Anderson, Robert S, Landis, Wayne G
Format: Report
Sprache:eng
Schlagworte:
AMIDES
Biochemistry
CLAMS
DIGESTIVE SYSTEM
FLUORIDATE/DIISOPROPYLPHOSPHORDIAMIDO
FLUORINE COMPOUNDS
GLANDS
HYDROLYSIS
KIDNEYS
Organic Chemistry
ORGANIC COMPOUNDS
PE61102A
PROTOZOA
RATES
SUBSTRATES
SWINE
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Zusammenfassung:The effect of mipafox (N,N'-diisopropylphosphordiamidofluoridate) on the DFPase activity of clam digestive gland was investigated. An increasing trend in hydrolysis rates resulted where mipafox activity DFP activity DFP with mipafox activity. Mipafox is a known inhibitor of DFPase from hog's kidney and Tetrahymena thermophila but does not inhibit squid-type DFPase. The observed additive effect of DFP with mipafox hydrolysis rates appears, in this case, to be a unique characteristic of Rangia-extract. Keywords: Amides; Fluorine compounds; Organic fluorine compounds.