Developmental Toxicology of Methylphosphonic Difluoride (DF)

The teratogenicity of vaporized methlyphosphonic difluoride (DF) was investigated using the rat and rabbit as the experimental models. Pregnant rats and rabbits were exposed. Dams and does exposed exhibited nasal exudate and raspy breathing. These dams also had significantly lower body weights on th...

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Bibliographische Detailangaben
Hauptverfasser:	Starke, William C, Burnett, David C, Hilaski, Roger J, Manthei, James H, Heitkamp, Dale H
Format:	Report
Sprache:	eng
Schlagworte:	AS554 BODY WEIGHT DAMS EXPERIMENTAL DESIGN FETUS FLUORIDES MEAN METHYL RADICALS METHYLPHOSPHONIC DIFLUORIDE ORGANOGENISIS PE62622A PHOSPHONATES PREGNANCY RABBITS RATS TERATOGENIC COMPOUNDS TERATOLOGY Toxicology
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Beschreibung
Zusammenfassung:	The teratogenicity of vaporized methlyphosphonic difluoride (DF) was investigated using the rat and rabbit as the experimental models. Pregnant rats and rabbits were exposed. Dams and does exposed exhibited nasal exudate and raspy breathing. These dams also had significantly lower body weights on the last three of four weighings. There were, however, no differences between the control litters and the DF-exposed litters for the parameters: litter number, mean body weight, mean crown-rump length, visceral or skeletal malformations. It was concluded that DF is not teratogenic in the rat or rabbit by the inhalation route at the concentrations tested. Keywords: Fetus; Teratogenic compounds; Gestation; Organogenesis; Pregnant.