Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes
The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 (formerly known as T17) in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodini...
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| creator | Baden, Daniel G Mende, Thomas J |
| description | The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 (formerly known as T17) in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodinium breve) bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. Keywords: Binding sites; Active sites; Membranes biology; Sodium channels; Brevetoxins; Toxins. |
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The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodinium breve) bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. 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The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodinium breve) bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. 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| language | eng |
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| source | DTIC Technical Reports |
| subjects | ACTIVE SITES ASS12 BINDERS BINDING SITES BREVETOXINS CHANNELS DINOFLAGELLATA DISSOCIATION EXCITATION Genetic Engineering and Molecular Biology MEMBRANES(BIOLOGY) NERVES NEUROTOXINS PE61102A PTYCHODISCUS BREVIS NEUROTOXIN RATS SODIUM SODIUM CHANNELS Toxicology TOXINS AND ANTITOXINS WU105 |
| title | Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes |
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