Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes

Characterization of the Ptychodiscus brevis Polyether Neurotoxin Binding Component in Excitable Membranes

The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 (formerly known as T17) in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodini...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Baden, Daniel G, Mende, Thomas J
Format: Report
Sprache:eng
Schlagworte:
ACTIVE SITES
ASS12
BINDERS
BINDING SITES
BREVETOXINS
CHANNELS
DINOFLAGELLATA
DISSOCIATION
EXCITATION
Genetic Engineering and Molecular Biology
MEMBRANES(BIOLOGY)
NERVES
NEUROTOXINS
PE61102A
PTYCHODISCUS BREVIS NEUROTOXIN
RATS
SODIUM
SODIUM CHANNELS
Toxicology
TOXINS AND ANTITOXINS
WU105
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Beschreibung
Zusammenfassung:The research is aimed at characterization of the binding site for Ptychodiscus brevis neurotoxin PbTx-3 (formerly known as T17) in nerve tissues, specifically in rat brain synaptosomes. The polyether lipid-soluble toxins isolated from the marine dinoflagellate Ptychodiscus brevis (formerly Gymnodinium breve) bind to a unique site, Site V, associated with the voltage- sensitive sodium channel probe for binding at Site V, dissociation constants and binding maxima have been determined in rat, fish, and turtle brain synaptosomes. Keywords: Binding sites; Active sites; Membranes biology; Sodium channels; Brevetoxins; Toxins.