Mutagenic Activity of Dimethylsulfoxide (DMSO) Solvent Samples from Munition Pilot Test Plant on Mammalian Cells

Mutagenic Activity of Dimethylsulfoxide (DMSO) Solvent Samples from Munition Pilot Test Plant on Mammalian Cells

Two DMSO solvent samples containing munition constituents contained a direct-acting mutagen(s). Of the two samples, DMSO recycle solvent sample had a more acute mutagenic activity than DMSO evaporator sludge sample at comparable dilution of the stock solution. The mutagenic activity in these samples...

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Bibliographische Detailangaben
Hauptverfasser: Kawakami, Thomas G, Aotaki-Keen, Amy
Format: Report
Sprache:eng
Schlagworte:
BIOASSAY
CELLS(BIOLOGY)
DIMETHYLSULFOXIDE
IN VITRO ANALYSIS
LPN-APO-3801
Medicine and Medical Research
METHYL RADICALS
MICE
MUTAGENS
SULFOXIDES
Toxicology
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Zusammenfassung:Two DMSO solvent samples containing munition constituents contained a direct-acting mutagen(s). Of the two samples, DMSO recycle solvent sample had a more acute mutagenic activity than DMSO evaporator sludge sample at comparable dilution of the stock solution. The mutagenic activity in these samples was not augmented with addition of rat liver S-9. Since these samples are a mixture of several compounds, the identity of the specific compound(s) responsible for the mutagenic activity is not known.