Dermal Sensitization Potential of Candidate Insect Repellents: LAIR Formulation (CHF1) N-(n-octyl) glutarimide (CHR2) N-(n-hexyl) glutarimide (CHR3) (E) 1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl)quinoline (CHR5) 1,2,3,4-tetrahydro-6-methyl-1-(3-methyl-1-oxo-2-butenyl) quinoline (CHR6)

Arthropods represent a potential disease threat to U.S. Military Forces; consequently, a program to develop improved insect repellents was developed. The dermal sensitization potential of candidate insect repellents was determined using guinea pigs. Test substances CHF1, CHR2, and CHR3 were clearly non-sensitizing. CHR5 and CHR6 were irritating, possibly sensitizing, and should be retested. (Author)