Drug Exposed to Extreme Cold: The Military Perspective

A list of drugs identified as being damaged by freezing (68 of 153 items) was excerpted from the 668 Authorized Medical Allowance List (AMAL). Freeze/thaw stability data was obtained from both the literature and innovator drug companies for over one half (45 of 68) of these items. A summary of recommendations for use in cold operations of these 68 items was prepared. Recommendations ranged from conservative (in those cases where no information was available) to liberal (where drug companies were concerned with efficacy). Recommendations also included the substitution of some items on the list with drugs of similar action but not needing freeze protection.