The Acute Toxicity of Polyethylene Glycol 200 in Laboratory Animals

The Acute Toxicity of Polyethylene Glycol 200 in Laboratory Animals

Mice and rats were exposed to polyethylene glycol 200 (PEG 200) aerosols by the inhalation route for 6 hours at a concentration of 2,516 mg/cu m. The LCt50 for PEG 500 is greater than the 905,760 mg min/cu m used in this study. No biologically significant alterations in blood chemistry, hematology,...

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Bibliographische Detailangaben
Hauptverfasser: Crook,James W, Hott,Paul, Weimer,John T, Farrand,Richard L, Cooper,Aubrey E
Format: Report
Sprache:eng
Schlagworte:
AEROSOLS
AS554
GLYCOLS
HEMATOLOGY
INHALATION
LABORATORY ANIMALS
MICE
PATHOLOGY
PE62622A
PHYSIOLOGICAL EFFECTS
Polyethylene glycol
RATS
TOXIC HAZARDS
TOXICITY
Toxicology
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Beschreibung
Zusammenfassung:Mice and rats were exposed to polyethylene glycol 200 (PEG 200) aerosols by the inhalation route for 6 hours at a concentration of 2,516 mg/cu m. The LCt50 for PEG 500 is greater than the 905,760 mg min/cu m used in this study. No biologically significant alterations in blood chemistry, hematology, or pulmonary resistance were found. No mutations or pathological abnormalities could be attributed to the PEG 200 exposure. Intravenous and oral toxicity tests in rats place PEG 200 in the relatively harmless class. (Author)