The Mutagenic Potential of: N-Hexyl-2-Oxazolidone

The Mutagenic Potential of: N-Hexyl-2-Oxazolidone

It has been shown that, with the Ames Assay, n-hexyl-2-oxazolidone is mutagenic to Salmonella strain TA 98 in the range of .00004 to 3.2 X 10 to the 7th power m1/plate. Since these same results were not observed for any of the other strains, it was concluded that the test substance functions as a we...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sauers,Leonard J, Pulliam,Freddica R, Fruin,John T
Format: Report
Sprache:eng
Schlagworte:
AS871
BIOASSAY
CULTURES(BIOLOGY)
DOSAGE
ENZYMES
HISTIDINE
INOCULATION
MICROSOMES
MUTAGENS
MUTATIONS
Oxazolidone/n-hexyl-2
PE62770A
RATS
SALMONELLA TYPHIMURIUM
STRAINS(BIOLOGY)
TOXICITY
Toxicology
WU201
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Beschreibung
Zusammenfassung:It has been shown that, with the Ames Assay, n-hexyl-2-oxazolidone is mutagenic to Salmonella strain TA 98 in the range of .00004 to 3.2 X 10 to the 7th power m1/plate. Since these same results were not observed for any of the other strains, it was concluded that the test substance functions as a weak frameshift mutagen. (Author)