Phase 8, Dermal Penetration of Radiolabeled Repellent N,N-Diethyl-m-toluamide (m-Det), January 1979 - June 1980

Phase 8, Dermal Penetration of Radiolabeled Repellent N,N-Diethyl-m-toluamide (m-Det), January 1979 - June 1980

The dermal penetration of 14C-labeled m-Det was measured in rats, rabbits, and dogs. Absorption was quantitated by monitoring radioactivity in excreta for 7 days and tissues at necropsy. Pregnant rabbits were repeatedly applied with the repellent and fetuses monitored for radioactivity at term. It i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Snodgrass,Hubert L , Jr, Nelson,Douglas C, Weeks,Maurice H
Format: Report
Sprache:eng
Schlagworte:
BIOLOGICAL ABSORPTION
DOGS
FETUS
INSECT REPELLENTS
LABELED SUBSTANCES
MONITORING
PENETRATION
RABBITS
RADIOACTIVE ISOTOPES
RATS
SKIN(ANATOMY)
Toluamide/N-N-Diethyl-M
Toluamides
TOXIC HAZARDS
Toxicology
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Beschreibung
Zusammenfassung:The dermal penetration of 14C-labeled m-Det was measured in rats, rabbits, and dogs. Absorption was quantitated by monitoring radioactivity in excreta for 7 days and tissues at necropsy. Pregnant rabbits were repeatedly applied with the repellent and fetuses monitored for radioactivity at term. It is concluded that topically applied m-Det should not present a dermatoxic hazard to man and absorption would be expected to be less than 10 percent of the applied dose. No affinity for specific tissue binding of the repellant has been demonstrated in these tests. (Author)