Evaluation of a Nuclease-Resistant Derivative of Poly(I) Poly(C) (Poly(ICLC)) as a Radioprotective Agent 1, 2

The synthetic double-stranded ribonucleic acid, polyriboinosinic acid polyribocytidylic acid (poly(I) poly(C)) is an interferon inducer, has antiviral and antitumor properties, and has been shown to be radioprotective in rodents. The observation that the radioprotective action of poly(I) poly(C), as...

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Bibliographische Detailangaben
Hauptverfasser:	Baze,Wallace B, Lvovsky,Eduard, Higbee,Glen A, Levy,Hilton B, Hilmas,Duane E
Format:	Report
Sprache:	eng
Schlagworte:	ANTIVIRAL AGENTS BLOOD SERUM CARBOXYMETHYLCELLULOSE CHEMICAL DERIVATIVES COBALT COMPLEX COMPOUNDS DOSAGE ENDOTOXINS INTERFERON INTRAMUSCULAR INJECTIONS MICE NUCLEASE PE62776A Pharmacology Poly-1-lysine Polyribocytidylic acid Polyriboinosinic acid RADIOPROTECTIVE AGENTS WHOLE BODY IRRADIATION WU008
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Zusammenfassung:	The synthetic double-stranded ribonucleic acid, polyriboinosinic acid polyribocytidylic acid (poly(I) poly(C)) is an interferon inducer, has antiviral and antitumor properties, and has been shown to be radioprotective in rodents. The observation that the radioprotective action of poly(I) poly(C), as well as certain endotoxins and chemicals, may be associated with their ability to induce interferon, has also stimulated interest in the possible radioprotective action of interferon itself.