The Exotoxin of P. aeruginosa: A Proenzyme Having an Unusual Mode of Activation

The Exotoxin of P. aeruginosa: A Proenzyme Having an Unusual Mode of Activation

The exotoxin of Pseudomonas aerguinosa is a proenzyme possessing latent ADPR-transferase activity. Conversion to the active form can be effected by simultaneous treatment with a protein denaturant and a chemical able to split disulfide bonds. Activation results from a conformational change that expo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Leppla, Stephen H, Muehl, Laura A, Martin, Ona C
Format: Report
Sprache:eng
Schlagworte:
ACTIVATION
ADENOSINE PHOSPHATES
CONFORMATIONAL ANALYSIS
ENZYMES
EXOTOXINS
Microbiology
PE62776A
Pharmacology
PROENZYMES
PSEUDOMONAS AERUGINOSA
Toxicology
WU046
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Beschreibung
Zusammenfassung:The exotoxin of Pseudomonas aerguinosa is a proenzyme possessing latent ADPR-transferase activity. Conversion to the active form can be effected by simultaneous treatment with a protein denaturant and a chemical able to split disulfide bonds. Activation results from a conformational change that exposes the previously buried active site. Proteolysis is not required.