The Relationship between the Concentrations of Serum Lipoproteins and Serum Lipids

In this laboratory current research procedures require that simultaneous measurements of blood lipoproteins and blood lipids be accomplished in an effort to estimate the risk of coronary disease. It has been suggested that little additional information is gained by the multiple determinations. These studies report (1) the extent of correlation between ultracentrifugally determined serum lipoproteins, (2) the errors of measurement involved in all determinations, and (3) age-specific values for all serum parameters in the same population. It was found that although a high correlation exists between a linear combination of ultracentrifugally determined lipoproteins and the serum concentrations of cholesterol and phospholipid, the prediction of lipoprotein levels from the purely chemical measurements is not entirely satisfactory. Therefore, for the time being at least, all measurements will have to be accomplished.