Toxicologic Studies with Didymium Nitrate as Modified by Site of Injection and Whole-Body Radiation

Toxicologic Studies with Didymium Nitrate as Modified by Site of Injection and Whole-Body Radiation

The rare-earth mixture didymium (as the nitrate) was administered to rats intraperitoneally, subcutaneously, and in wound implantation. Mortality and clinical sequelae were observed. When groups of these animals were subjected to 800 r of Co60 gamma irradiation, mortality was increased in all treatm...

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Bibliographische Detailangaben
Hauptverfasser: Melville,George S , Jr, Leffingwell,Thomas P, Hartwig,Quentin L
Format: Report
Sprache:eng
Schlagworte:
Didymium nitrate
LETHAL DOSAGE
MORTALITY RATE
RARE EARTH COMPOUNDS
RATS
SODIUM NITRATES
TOXICITY
Toxicology
WHOLE BODY IRRADIATION
WOUNDS AND INJURIES
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Zusammenfassung:The rare-earth mixture didymium (as the nitrate) was administered to rats intraperitoneally, subcutaneously, and in wound implantation. Mortality and clinical sequelae were observed. When groups of these animals were subjected to 800 r of Co60 gamma irradiation, mortality was increased in all treatment groups. This increase was statistically significant in the intraperitoneal experiment and the COmbined effect appears to be synergistic. (Author)