Retinal Changes Induced by Heavy Particles: A New Therapy Modality

The effects of accelerated oxygen nuclei upon the retina of a nonhuman primate have been investigated. This simulated deep space radiation affords the possibility of delivering great quantities of energy (at a predetermined depth) within the eye, while but minimally irradiating interposing tissues. When compared with the clinical results following the use of cobalt plaques the oxygen ion has demonstrated a significant compression of both time and dose in achieving the same degree of tissue effect. Therefore, the possibility obtains for a greater local irradiation of intraocular neoplasta with a sharp reduction of radiation damage to surrounding non-neoplastic ocular tissues.