Hazard Evaluation of Candidate Face Net Impregnant ENT-337 DI-Dibutyl Malate

Hazard Evaluation of Candidate Face Net Impregnant ENT-337 DI-Dibutyl Malate

A hazard evaluation of the candidate face net impregnant dl-dibutyl malate (ENT-337) was performed by means of laboratory animal studies using rats and rabbits. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. Mild injury to the c...

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Bibliographische Detailangaben
Hauptverfasser: Macko,Joseph A , Jr, Weeks,Maurice H
Format: Report
Sprache:eng
Schlagworte:
AEROSOLS
BIOASSAY
EXPERIMENTAL DATA
EXPOSURE(PHYSIOLOGY)
FACE(ANATOMY)
HAZARDS
HISTOLOGY
Impregnants
INGESTION(PHYSIOLOGY)
INHALATION
INSECT REPELLENTS
LABORATORY ANIMALS
LETHAL DOSAGE
MALIC ACID
Malic acid/(dibutyl-ester)
NETS
PATHOLOGY
SKIN(ANATOMY)
TOXICITY
Toxicology
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Beschreibung
Zusammenfassung:A hazard evaluation of the candidate face net impregnant dl-dibutyl malate (ENT-337) was performed by means of laboratory animal studies using rats and rabbits. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. Mild injury to the cornea and slight chemosis, redness and discharge of the conjunctiva resulted from single application to the eyes of rabbits. Data indicated little toxic hazard from accidental ingestion. Acute aerosol and subchronic saturated vapor inhalation exposures of rats resulted experimentally in no deleterious effect.