Acute Systemic Toxicity of Pure Dimercaprol and Trimercaptopropane
The presence of 1,2,3-trimercaptopropane in dimercaprol (2,3-dimercapto-1-propanol, British anti-lewisite) is the cause of significant variations in reported toxicity values of dimercaprol. When injected intramuscularly in rats and mice, trimercaptone-free dimercaprol is approximately one-fifth as t...
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| Zusammenfassung: | The presence of 1,2,3-trimercaptopropane in dimercaprol (2,3-dimercapto-1-propanol, British anti-lewisite) is the cause of significant variations in reported toxicity values of dimercaprol. When injected intramuscularly in rats and mice, trimercaptone-free dimercaprol is approximately one-fifth as toxic as toxic as an equivalent amount of trimercaptopropane. No synergistic effects between the two compounds were found. |
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