Hazard Evaluation of Candidate Face Net Impregnant Ent-20831 Bis(1-Methylbutyl) Malate Study

Hazard Evaluation of Candidate Face Net Impregnant Ent-20831 Bis(1-Methylbutyl) Malate Study

A hazard evaluation of the candidate face net impregnant, bis(1-methylbutyl) malate (ENT-20831), was performed by means of laboratory animal studies using rats and rabbits. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. No corne...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Pope,Conrad R, Weeks,Maurice H, Macko,Joseph A , Jr
Format: Report
Sprache:eng
Schlagworte:
BIOASSAY
DOSAGE
EYE
IMPREGNATION
INGESTION(PHYSIOLOGY)
INHALATION
INSECT REPELLENTS
IRRITATING AGENTS
LETHAL DOSAGE
MALIC ACID
Malic acid/bis(methylbutyl-ester)
NETS
PERMISSIBLE DOSAGE
RABBITS
RATS
Recommendations
SKIN(ANATOMY)
Toxicology
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Beschreibung
Zusammenfassung:A hazard evaluation of the candidate face net impregnant, bis(1-methylbutyl) malate (ENT-20831), was performed by means of laboratory animal studies using rats and rabbits. The technical grade compound did not produce primary irritation when applied to the intact or abraded skin of rabbits. No corneal injury, iritis or conjunctivitis was observed after a single application of the technical grade compound to the eyes of rabbits. Data indicate little acute toxic hazard from accidential ingestion. Acute aerosol and subchronic saturated vapor inhalation exposures of rats resulted experimentally in no deleterious effect. It is recommended that ENT-20831 be approved for testing as a candidate face net impregnant.