Primary Irritation Evaluation Program Study

Primary Irritation Evaluation Program Study

1-Decanoyl-4-methylpiperazine (AI3-36250-Ga), 4-(6-Methyl-3-cyclohexenecarbonyl) morpholine (AI3-36258-Ga), 4-(2-Methylcyclohexanecarbonyl)morpholine (AI3-36260), and 1-Decanoyl-1,3,4,6-tetrahydropyridine (AI3-36307-Ga), which are insect repellents were evaluated on New Zealand White rabbits for the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: Fisch,Harvey
Format: Report
Sprache:eng
Schlagworte:
BIOASSAY
CHEMICAL COMPOUNDS
CYCLOHEXANES
CYCLOHEXENES
Decanone/ tetrahydropyridyl
Decanone/methylpiperazinyl
EYE
HUMANS
INSECT REPELLENTS
IRRITATION
Ketone/ methylcyclohexenyl-morpholino
Ketone/methylcyclohexyl-morpholine
KETONES
Pharmacology
Piperazines
PYRIDINES
RABBITS
Recommendations
SKIN(ANATOMY)
TOXICITY
Toxicology
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Beschreibung
Zusammenfassung:1-Decanoyl-4-methylpiperazine (AI3-36250-Ga), 4-(6-Methyl-3-cyclohexenecarbonyl) morpholine (AI3-36258-Ga), 4-(2-Methylcyclohexanecarbonyl)morpholine (AI3-36260), and 1-Decanoyl-1,3,4,6-tetrahydropyridine (AI3-36307-Ga), which are insect repellents were evaluated on New Zealand White rabbits for their potential to cause skin irritation. The data obtained serve as a basis for making a recommendation concerning their potential use on humans. This recommendation is intended only for guidance in further entomological testing of these compounds. Also includes Rept. no. USAEHA-51-039-75, and USAEHA-51-041-75.