Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis

Studying the Immunomodulatory Effects of Small Molecule Ras Inhibitors in Animal Models of Rheumatoid Arthritis

During the first two year of the award, we made several high impact key observations:(I) Prophylactic treatment with Farnesylthiosalicylic acid (FTS), a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis (AIA) model by al...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Goldstein , Itamar, Kloog,Yoel, Zayoud,Morad, Sfadia,Galit E, Moshe,Itzhak B, Vax,Einav, Ben Moshe,Itzhak
Format: Report
Sprache:eng
Schlagworte:
ANGIOTENSIN
arthritis
cells (biology)
dmards(disease-modifying antirheumatic drugs)
fts(Farnesylthiosalicylic acid)
IMMUNOMODULATION
inflammation
inhibitors
Medicine and Medical Research
ra(Rheumatoid Arthritis)
Ras GTPases
ras(renin-angiotensin system)
T helper cells
targeted synthetic DMARDs
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:During the first two year of the award, we made several high impact key observations:(I) Prophylactic treatment with Farnesylthiosalicylic acid (FTS), a first-in-class oral selective RAS inhibitor, provides a significant immunomodulatory effect in the rat adjuvant-induced arthritis (AIA) model by all outcome parameters(Clinical assessment and relevant laboratory/immunological/Molecular analyses). (II) Prophylactic dosing of FTS combined with methotrexate (MTX) provides a synergistic protective effect (90 disease inhibition).(III) The FTS derivative, F-FTS, showed superior therapeutic clinical efficacy compared to FTS in the AIA model.