A Proposed Mechanism for Hypobaria Induced Neuronal Injury: A Swine Model

Non-hypoxic hypobaric exposure in Air Force U-2 pilots and hypobaric chamber personnel is associated with increased brain white matter hyperintensities (WMH) and decrements in neurocognitive processing. The mechanism for this is unknown. We hypothesized that if injury is due to diffuse axonal degrad...

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Hauptverfasser:	Peralta,Philippine D, Sladky,John H, Sherman,Paul, McGuire,Stephen A
Format:	Report
Sprache:	eng
Schlagworte:	altitude Anatomy and Physiology anisotropy axonal damage AXONS DIFFUSION exposure (physiology) hypobaria-induced neuronal injuries kurtosis anisotropy MAGNETIC RESONANCE IMAGING Medicine and Medical Research mri (MAGNETIC RESONANCE IMAGING) multi-b-value diffusion NEURONS non-hypoxic hypobaria pdi (perfusion diffusion index) PIGS Q-space siwne models water diffusion wmh (white matter hyperintensities) wounds and injuries
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Zusammenfassung:	Non-hypoxic hypobaric exposure in Air Force U-2 pilots and hypobaric chamber personnel is associated with increased brain white matter hyperintensities (WMH) and decrements in neurocognitive processing. The mechanism for this is unknown. We hypothesized that if injury is due to diffuse axonal degradation, this would manifest as changes in unrestricted water diffusion and be demonstrable through diffusion magnetic resonance imaging (MRI), utilizing advanced techniques such as multi-b-value diffusion (Q-space) and kurtosis anisotropy. We developed a swine model to test this theory. 2017 AAN (American Academy of Neurology) Annual Meeting, 22 Apr 2017, 28 Apr 2017,