GCMS/MS Analyses of Biological Samples in Support of Evaluation of Toxicity Associated with Intravenous Exposure to VX Stereoisomers in Guinea Pigs

This report documents the results of the gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs (heart, lung, liver, kidney, and brain) that were obtained from guinea pigs intravenously exposed to various concentrations of O-ethyl S-(2-diisopropylaminoethyl) methylphospho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	McGuire, Jeffrey M, Wright,Linnzi K, Kristovich,Robert L, Busch,Michael W
Format:	Report
Sprache:	eng
Schlagworte:	assays Biology blood Chemical, Biological and Radiological Warfare exposure (physiology) gas chromatography GCMS MS (Gas chromatographytandem mass spectrometry) guinea pigs Intravenous exposure Isotope dilution LD50 (median lethal dose) mass spectrometry ORGANS (ANATOMY) Pharmacokinetics Range-Finding sampling STEREOISOMERS tissues (biology) toxicity Toxicology vx (O-ethyl S- 2-diisopropylaminoethyl methylphosphonothioate) VX AGENT VX-G (O-ethyl methylphosphonofluoridate)
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	This report documents the results of the gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs (heart, lung, liver, kidney, and brain) that were obtained from guinea pigs intravenously exposed to various concentrations of O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) stereoisomers. The amount of O-ethyl methylphosphonofluoridate (VX-G) present in these biological samples was quantified using chemical ionization mass spectrometry with isotope dilution.