The Effect of Diazoxide Upon Heat Shock Protein and Physiological Response to Hemorrhagic Shock and Cerebral Stroke

The Effect of Diazoxide Upon Heat Shock Protein and Physiological Response to Hemorrhagic Shock and Cerebral Stroke

Our team tested the hypothesis that pharmacological induction of ischemicpreconditioning (IPC) can offer cytoprotection and preserve vital tissues after cerebralstroke with hemorrhagic shock. The compound, diazoxide (DZ), is known to mimic IPCthrough its effects as a mitochondrial KATP channel opene...

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Bibliographische Detailangaben
1. Verfasser: O'Sullivan,Joseph C
Format: Report
Sprache:eng
Schlagworte:
brain
brain injuries
cardiovascular system
cerebral vascular occlusion
drug therapy
dZ(diazoxide)
hemorrhage
hemorrhagic shock
hyperlactatemia
proteins
stress(physiology)
Strokes(cerebral)
therapeutics
vascular diseases
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Zusammenfassung:Our team tested the hypothesis that pharmacological induction of ischemicpreconditioning (IPC) can offer cytoprotection and preserve vital tissues after cerebralstroke with hemorrhagic shock. The compound, diazoxide (DZ), is known to mimic IPCthrough its effects as a mitochondrial KATP channel opener and succinate dehydrogenaseinhibitor. The effect of DZ was examined under two IPC protocols: delayedpreconditioning and postconditioning in an anesthetized rat model of hemorrhagic shock,combined in some experimental groups with cerebral vascular occlusion (stroke). [truncated]